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  • steam
  • GameCharts     Steam    Genome Guardian
    Month Avg. Players Gain % Gain Peak Players
    December 2025 9 3 50% 29
    November 2025 6 0 0% 17
    October 2025 6 -2 -25% 20
    September 2025 8 -25 -75.76% 26
    August 2025 33 20 153.85% 221
    July 2025 13 -6 -31.58% 31
    June 2025 19 -6 -24% 46
    May 2025 25 -7 -21.88% 47
    April 2025 32 11 52.38% 82
    March 2025 21 10 90.91% 129
    February 2025 11 -6 -35.29% 26
    January 2025 17 2 13.33% 41
    December 2024 15 -5 -25% 41
    November 2024 20 -29 -59.18% 47
    October 2024 49 26 113.04% 261
    September 2024 23 -11 -32.35% 60
    August 2024 34 -68 -66.67% 88
    July 2024 102 84 466.67% 183
    June 2024 18 15 500% 180
    May 2024 3 3 --- 14
    April 2024 0 --- --- 0

    About Genome Guardian

    WISHLIST TODAY!




    Dive into a microscopic alien world, radiating with bioluminescent life and unspeakable horrors. Genome Guardian is a deeply-complex shooter that's easy to pick up but hard to master. Research permanent upgrades to survive 70 different microbes across 4 game modes, each with multiple ascension levels ("depths").



    Pair DNA nucleotides Adenine (rapidfire), Cytosine (precision), Guanine (spread), Thymine (explosive) to discover wild hybrid bioweapons!
    • Bomb + Shotgun combines explosives with spread to create Blast Shotgun!
    • Bomb + Bomb doubles down on explosive power to make Bazooka!
    • Blast Shotgun + Shotgun forms the all-powerful Flak Cannon!
    Learn more about each weapon and microbe in the database containing all ...